1.
Arab Journal of Pharmaceutical Sciences. 2003; 2 (6): 11-20
in Arabic
| IMEMR
| ID: emr-61579
ABSTRACT
The goal of this study was to evaluate the anti-tumor activity of two Enkephalin analogues designed and synthesized using a conventional solution method. The anti-tumor activity of these two analogues was studied in-vitro following National cancer institute [NCI] protocol [USA]. The results confirmed that the synthesized Leu- Enkephalin analogue [analogue 1] have a positive effect on all cell lines tested indicating its effectiveness as anti-tumor compound on many cancers especially those of lungs, colon and breast. Met-Enkephalin analogue [ana1ogue II] showed no effect on any type of tumor cells tested. In conclusion analogue I can be considered as a novel promising anticancer compound